[Pete's ninth in the series to help clarify zoning laws, as well as rights neighborhoods have during proposed zoning changes or variances.]
Taking a few steps to be aware will give you peace of mind. When you purchase a home, part of the due diligence your attorney should do is to examine the zoning map, understand the codes for your district, and alert you to any potential problems, such as commercial development, nearby. After that you are on your own.